ABSTRACT
One of the health problems which is associated during the management of a patient with series of drugs is ADR/ADE. Therefore, the aim of the present study was to find out the activities for improving the reporting of ADRs/ADEs. The data on the KAP is collected on a pre-tested questionnaire.METHODSThis is a non-interventional cross-sectional study. The questionnaire was prepared after referring the questionnaires of previous studies. Out of 120 questionnaires distributed, only 100 questionnaires were received back. Descriptive statistics is used for analysing the data.RESULTSThe response on the questionnaire is 83.3%. Seventy-nine (79) participants knew the definition of ADR/ADE. Eighty-eight (88) participants want to report the ADRs of the marketed drugs irrespective of new or old. Seventy-five (75) participants know about PvPI. Ninety (90) participants do not consider all the OTC and Herbal drugs are safe. Seventy-two (72) participants do not know the establishment of a Pharmacovigilance centre at the Department of Pharmacology, JNIMS. Only 55.6% of the participants oblige to report the ADRs as a professional health care provider. 58% of the participants opine to conduct a regular CME program on ADR/Pharmacovigilance. 63.2% participants state that maximum ADRs are seen among dermatological, paediatric and elderly patients. 58.2% of the participants express their opinion about the occurrence of ADRs/ADEs with irrational prescription, polypharmacy, foods, drinks etc. 44% participants have the attitude of reporting ADRs/ADEs but only 10% participants perform the actual reporting with careful observations on patients’ behaviour. Most of the ADRs/ADEs are avoidable if there is good communication and reporting.CONCLUSIONSA regular awareness programme on ADR/ADE along with CME program and also online reporting facilities is necessary for promotion of reporting of the ADR/ADE. Therefore, the drug should be prescribed rationally, and polypharmacy should be avoided as much as possible.
ABSTRACT
Background: The therapy of antibiotics among the paediatric patients may produce any type of adverse effects as the organs of infants and children are immature and the genetic constituents are also not fully known. The empirical use of antibiotic may also produce antibiotic resistance. Aim was to study the prescribing pattern of antibiotics among the paediatric patients.Methods: It was a retrospective, observational study for a period of six months. The collected data included age, sex, diagnosis and line of management. Generic name and average cost of treatment per patient was evaluated by using CIMS 2019 and Bhartiya Jan Aushadhi Pariyojna. The descriptive statistics was applied for the detail data analysis.Results: Bed head tickets (BHTs) of 560 inpatients was examined. The common diagnosis were AGE (193; 34.4%) and ARI (60; 10.7%). The route of administration were oral 279 (49.8%) and parenteral 281 (50.1%). The duration of hospital stay were in between 5 days (141; 25.1%) to 7 days (61; 10.8%). The minimum and maximum age of the patient were 3 months and 12 years respectively. The most common antibiotic used was ceftriaxone and metronidazole. The number of patient received single antibiotic was 295 (52.6%) and multiple used was 265 (47.3%). The number of antibiotic prescribed from NLEM and Pariyojna were 9 and 13 respectively. The average cost of treatment per patient was Rs. 345.00 (CIMS) and Rs. 119.90 (Pariyojna) approximately.Conclusions: The antibiotics prescribed by generic name was not satisfactory. The proposal for wide awareness programme may be suggested to the concerned authority for improving the prescribing practice among the physicians at different levels.
ABSTRACT
Background: Traditionally, the bark of Pavetta Indica Linn., in decoction or pulverized, is administered, especially to children, to correct visceral obstructions. The decocted leaves are used externally to alleviate the pains caused by hemorrhoids. The root, pulverized and mixed with the ginger and rice-water, is given in dropsy. A local fomentation with the leaves is useful in relieving the pain of piles. Paracetamol (PCM) toxicity generates free radicals and raised serum enzyme levels-SGPT, SGOT, Alkaline Phosphatase and S. Albumin. It causes necrosis, congested vessels, multifocal area of fatty changes nuclear disintegration, sinusoidal dilation, kuffer cell hyperplasia. The reverse is considered as the index of hepatoprotective activity. The present study is being taken up to screen hepatoprotective action of P. Indica Linn.Methods: The acute liver damage in albino rats was induced by per oral administration of a single dose of 2000mg/kg b.w. PCM suspension in 0.5% Carboxy methyl cellulose (CMC) and chronic liver damage by giving the same dose of PCM on the 7th day. The hepatoprotective activity was monitored biochemically by estimating S. transaminase, S. bilirubin and S. Protein on the 8th day of experiment.Results: Ethanol extract of P. Indica inhibited PCM induced liver toxicity in albino rats at 100mg/kg and 200mg/kg b.w as assessed by the biochemical values.Conclusions: Ethanol extract of “P. Indica” exhibited significant hepatoprotective activity.
ABSTRACT
Objective: To study the protective effect of ethyl acetate extract of Acacia catechu in carbon tetrachloride induced hepatotoxicity in albino rats. Methods: The liver damage in albino rat was induced by a subcutaneous injection of 50%v/ v carbon tetrachloride in olive oil at the dose of 2ml/kg twice a week for 14days. The hepatoprotective activity was monitored biochemically by estimating serum transaminases, serum alkaline phosphatase, serum bilirubin and serum protein after intraperitoneal injection of ethyl acetate extract of Katha(250mg/kg). Silymarin(5mg/kg.I.P) was given as a reference drug. The histopathological changes of liver samples were compared with that of control. Results: Ethyl acetate extract of Acacia catechu inhibited carbon tetrachloride induced liver toxicity in albino rats at 250mg/kg body weight as assessed by the biochemical and histological examination. Conclusion: Ethyl acetate extract of “Katha” exhibited significant hepatoprotective activity.